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  1. The homeodomain transcription factor orthopedia (Otp) is an evolutionarily conserved regulator of neuronal fates. In vertebrates, Otp is necessary for the proper development of different regions of the brain a...

    Authors: Jose Arturo Gutierrez-Triana, Ulrich Herget, Patrick Lichtner, Luis A Castillo-Ramírez and Soojin Ryu

    Citation: BMC Developmental Biology 2014 14:41

    Content type: Research article

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  2. The sub-cortical maternal complex (SCMC), located in the subcortex of mouse oocytes and preimplantation embryos, is composed of at least four proteins encoded by maternal effect genes: OOEP, NLRP5/MATER, TLE6 ...

    Authors: Daniela Bebbere, Federica Ariu, Luisa Bogliolo, Laura Masala, Ombretta Murrone, Mauro Fattorini, Laura Falchi and Sergio Ledda

    Citation: BMC Developmental Biology 2014 14:40

    Content type: Research article

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  3. The switch from cartilage template to bone during endochondral ossification of the growth plate requires a dynamic and close interaction between cartilage and the developing vasculature. Vascular invasion of t...

    Authors: Sonja M Walzer, Erdal Cetin, Ruth Grübl-Barabas, Irene Sulzbacher, Beate Rueger, Werner Girsch, Stefan Toegel, Reinhard Windhager and Michael B Fischer

    Citation: BMC Developmental Biology 2014 14:36

    Content type: Research article

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  4. Members of the Semaphorin 3 family (Sema3s) influence the development of the central nervous system, and some are implicated in regulating aspects of visual system development. However, we lack information abo...

    Authors: Anil Sharma, Chrisna J LeVaillant, Giles W Plant and Alan R Harvey

    Citation: BMC Developmental Biology 2014 14:34

    Content type: Research article

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    The Erratum to this article has been published in BMC Developmental Biology 2014 14:39

  5. The 14-3-3 (YWHA) proteins are highly conserved in higher eukaryotes, participate in various cellular signaling pathways including cell cycle regulation, development and growth. Our previous studies demonstrat...

    Authors: Cheng Cui, Xiuli Ren, Dajun Liu, Xin Deng, Xin Qin, Xiangyu Zhao, Enhua Wang and Bingzhi Yu

    Citation: BMC Developmental Biology 2014 14:33

    Content type: Research article

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  6. To gain insight into what differences might restrict the capacity for limb regeneration in Xenopus froglets, we used High Performance Liquid Chromatography (HPLC)/double mass spectrometry to characterize protein ...

    Authors: Nandini Rao, Fengyu Song, Deepali Jhamb, Mu Wang, Derek J Milner, Nathaniel M Price, Teri L Belecky-Adams, Mathew J Palakal, Jo Ann Cameron, Bingbing Li, Xiaoping Chen and David L Stocum

    Citation: BMC Developmental Biology 2014 14:32

    Content type: Research article

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  7. Morphometric quantification of subtle craniofacial variation in studies of experimentally modified embryonic mice has proved valuable in determining the effects of developmental perturbations on craniofacial m...

    Authors: Christopher J Percival, Rebecca Green, Ralph Marcucio and Benedikt Hallgrímsson

    Citation: BMC Developmental Biology 2014 14:31

    Content type: Methodology article

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  8. Histone deacetylases (HDACs) play important roles in glial cell development and in disease states within multiple regions of the central nervous system. However, little is known about HDAC expression or functi...

    Authors: Sarika Tiwari, Subramanian Dharmarajan, Mahesh Shivanna, Deborah C Otteson and Teri L Belecky-Adams

    Citation: BMC Developmental Biology 2014 14:30

    Content type: Research article

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  9. The retinal pigmented epithelium (RPE) is a rounded shaped structure in almost all lizards. In the New World dwarf geckos, this structure shows an unusual morphology. In addition to this ocular character, we d...

    Authors: Ricardo A Guerra-Fuentes, Juan D Daza and Aaron M Bauer

    Citation: BMC Developmental Biology 2014 14:29

    Content type: Research article

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  10. Dimethyl sulfoxide (DMSO) is used extensively as a permeable cryoprotectant and is a common solvent utilized for several water-insoluble substances. DMSO has various biological and pharmacological activities; ...

    Authors: Dongjie Zhou, Xinghui Shen, Yanli Gu, Na Zhang, Tong Li, Xi Wu and Lei Lei

    Citation: BMC Developmental Biology 2014 14:28

    Content type: Research article

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  11. The Drosophila heart (dorsal vessel) is a relatively simple tubular organ that serves as a model for several aspects of cardiogenesis. Cardiac morphogenesis, proper heart function and stability require structural...

    Authors: Dominik Hollfelder, Manfred Frasch and Ingolf Reim

    Citation: BMC Developmental Biology 2014 14:26

    Content type: Research article

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  12. The developing vertebrate hindbrain is transiently segmented into rhombomeres by a process requiring Hox activity. Hox genes control specification of rhombomere fates, as well as the stereotypic differentiation o...

    Authors: Steven E Weicksel, Ankit Gupta, Denise A Zannino, Scot A Wolfe and Charles G Sagerström

    Citation: BMC Developmental Biology 2014 14:25

    Content type: Research article

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  13. Chloride Intracellular Channel 4 (CLIC4) is one of seven members in the closely related CLIC protein family. CLIC4 is involved in multiple cellular processes including apoptosis, cellular differentiation, infl...

    Authors: VC Padmakumar, Katelyn E Masiuk, Dror Luger, Christina Lee, Vincenzo Coppola, Lino Tessarollo, Shelley B Hoover, Irina Karavanova, Andres Buonanno, R Mark Simpson and Stuart H Yuspa

    Citation: BMC Developmental Biology 2014 14:24

    Content type: Research article

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  14. The DNA damage-mediated cell cycle checkpoint is an essential mechanism in the DNA damage response (DDR). During embryonic development, the characteristics of cell cycle and DNA damage checkpoint evolve from a...

    Authors: Xiao Qi Wang, Kwok Kin Chan, Xiaoyan Ming, Vincent CH Lui, Randy YC Poon, Chung Mau Lo, Chris Norbury and Ronnie TP Poon

    Citation: BMC Developmental Biology 2014 14:23

    Content type: Research article

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  15. The purple sea urchin, Strongylocentrotus purpuratus, has long been the focus of developmental and ecological studies, and its recently-sequenced genome has spawned a diversity of functional genomics approaches.

    Authors: Andreas Heyland and Jason Hodin

    Citation: BMC Developmental Biology 2014 14:22

    Content type: Methodology article

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  16. Bone marrow derived mesenchymal stem cells (bmMSCs) are multipotent cells that can differentiate into diverse cell types, including cardiomyocytes. BmMSC-based transplantation is capable of repairing acute and...

    Authors: Junfang Wu, Jie Niu, Xiaopeng Li, Xianwei Wang, Zhikun Guo and Fenxi Zhang

    Citation: BMC Developmental Biology 2014 14:21

    Content type: Research article

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  17. Circadian clocks have been postulated to regulate development time in several species of insects including fruit flies Drosophila melanogaster. Previously we have reported that selection for faster pre-adult deve...

    Authors: Pankaj Yadav, Madhumohan Thandapani and Vijay Kumar Sharma

    Citation: BMC Developmental Biology 2014 14:19

    Content type: Research article

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  18. The outermost layer of the vertebrate heart, the epicardium, forms from a cluster of progenitor cells termed the proepicardium (PE). PE cells migrate onto the myocardium to give rise to the epicardium. Impaire...

    Authors: Jessica S Plavicki, Peter Hofsteen, Monica S Yue, Kevin A Lanham, Richard E Peterson and Warren Heideman

    Citation: BMC Developmental Biology 2014 14:18

    Content type: Research article

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  19. Hox genes encode master regulators of regional fate specification during early metazoan development. Much is known about the initiation and regulation of Hox gene expression in Drosophila and vertebrates, but ...

    Authors: Wan-Ju Liu, John S Reece-Hoyes, Albertha JM Walhout and David M Eisenmann

    Citation: BMC Developmental Biology 2014 14:17

    Content type: Research article

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  20. The miniature pig provides an excellent experimental model for tooth morphogenesis because its diphyodont and heterodont dentition resembles that of humans. However, little information is available on the proc...

    Authors: Tieli Song, Tingting Wu, Fulan Wei, Ang Li, Fu Wang, Yilin Xie, Dayong Liu, Zhipeng Fan, Xuejiu Wang, Shan Cheng, Chunmei Zhang, Junqi He and Songlin Wang

    Citation: BMC Developmental Biology 2014 14:16

    Content type: Research article

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  21. Mosquito eggshells show remarkable diversity in physical properties and structure consistent with adaptations to the wide variety of environments exploited by these insects. We applied proteomic, transcriptomi...

    Authors: Osvaldo Marinotti, Tuan Ngo, Bianca B Kojin, Shao-Pei Chou, Brian Nguyen, Jennifer Juhn, Rebeca Carballar-Lejarazú, Pedro N Marinotti, Xiaofang Jiang, Marika F Walter, Zhijian Tu, Paul D Gershon and Anthony A James

    Citation: BMC Developmental Biology 2014 14:15

    Content type: Research article

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  22. Serotonin (5-HT) is well known as widely distributed modulator of developmental processes in both vertebrates and invertebrates. It is also the earliest neurotransmitter to appear during neuronal development. ...

    Authors: Konstantin Glebov, Elena E Voronezhskaya, Marina Yu Khabarova, Evgeny Ivashkin, Leonid P Nezlin and Evgeni G Ponimaskin

    Citation: BMC Developmental Biology 2014 14:14

    Content type: Research article

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  23. Differences in cranial morphology arise due to changes in fundamental cell processes like migration, proliferation, differentiation and cell death driven by genetic programs. Signaling between fibroblast growt...

    Authors: Susan M Motch Perrine, Theodore M Cole III, Neus Martínez-Abadías, Kristina Aldridge, Ethylin Wang Jabs and Joan T Richtsmeier

    Citation: BMC Developmental Biology 2014 14:8

    Content type: Research article

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  24. The development of blood flow in the heart is crucial for heart function and embryonic survival. Recent studies have revealed the importance of the extracellular matrix and the mechanical stress applied to the...

    Authors: Tomomi Watanabe-Asaka, Yoshio Sekiya, Hironori Wada, Takako Yasuda, Ikuya Okubo, Shoji Oda and Hiroshi Mitani

    Citation: BMC Developmental Biology 2014 14:12

    Content type: Research article

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  25. Flatfish metamorphosis is a hormone regulated post-embryonic developmental event that transforms a symmetric larva into an asymmetric juvenile. In altricial-gastric teleost fish, differentiation of the stomach...

    Authors: Ana S Gomes, Yuko Kamisaka, Torstein Harboe, Deborah M Power and Ivar Rønnestad

    Citation: BMC Developmental Biology 2014 14:11

    Content type: Research article

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  26. Important knowledge about the role of vitamin A in vertebrate heart development has been obtained using the vitamin A-deficient avian in ovo model which enables the in vivo examination of very early stages of ver...

    Authors: Inese Cakstina, Una Riekstina, Martins Boroduskis, Ilva Nakurte, Janis Ancans, Maija H Zile and Indrikis Muiznieks

    Citation: BMC Developmental Biology 2014 14:10

    Content type: Research article

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  27. Essentially nothing is known about the genetic regulation of olfactory system development in vector mosquitoes, which use olfactory cues to detect blood meal hosts. Studies in Drosophila melanogaster have identif...

    Authors: Keshava Mysore, Emily Andrews, Ping Li and Molly Duman-Scheel

    Citation: BMC Developmental Biology 2014 14:9

    Content type: Research article

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  28. Tissue injury has been employed to study diverse biological processes such as regeneration and inflammation. In addition to physical or surgical based methods for tissue injury, current protocols for localized...

    Authors: José Moya-Díaz, Oscar A Peña, Mario Sánchez, Daniela A Ureta, Nicole G Reynaert, Consuelo Anguita-Salinas, Gonzalo Marín and Miguel L Allende

    Citation: BMC Developmental Biology 2014 14:7

    Content type: Methodology article

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  29. After completion of embryogenesis, many organisms experience an additional obligatory developmental transition to attain a substantially different juvenile or adult form. During anuran metamorphosis, the aquat...

    Authors: Taka-Aki Ichu, Jun Han, Christoph H Borchers, Mary Lesperance and Caren C Helbing

    Citation: BMC Developmental Biology 2014 14:5

    Content type: Research article

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  30. The injection of Neb-colloostatin into T. molitor females causes gonadoinhibitory effects on ovarian development. This peptide inhibits intercellular space formation (patency) in follicular epithelium and results...

    Authors: Elżbieta Czarniewska, Grzegorz Rosiński, Elżbieta Gabała and Mariola Kuczer

    Citation: BMC Developmental Biology 2014 14:4

    Content type: Research article

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  31. LIM domain binding protein 1 (LDB1) is a transcriptional co-factor, which interacts with multiple transcription factors and other proteins containing LIM domains. Complete inactivation of Ldb1 in mice resulted in...

    Authors: Asma Almaidhan, Jeffry Cesario, Andre Landin Malt, Yangu Zhao, Neeti Sharma, Veronica Choi and Juhee Jeong

    Citation: BMC Developmental Biology 2014 14:3

    Content type: Research article

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  32. The editors of BMC Developmental Biology would like to thank all our reviewers who have contributed to the journal in Volume 13 (2013).

    Authors: Philippa K Harris

    Citation: BMC Developmental Biology 2014 14:1

    Content type: Reviewer acknowledgement

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  33. Krüppel-like Factor 2 (KLF2) plays an important role in vessel maturation during embryonic development. In adult mice, KLF2 regulates expression of the tight junction protein occludin, which may allow KLF2 to ...

    Authors: Aditi R Chiplunkar, Benjamin C Curtis, Gabriel L Eades, Megan S Kane, Sean J Fox, Jack L Haar and Joyce A Lloyd

    Citation: BMC Developmental Biology 2013 13:40

    Content type: Research article

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  34. Disabled-2 (Dab2) is an endocytic adaptor protein involved in clathrin-mediated endocytosis and cargo trafficking. Since its expression is lost in several cancer types, Dab2 has been suggested to be a tumor su...

    Authors: Robert Moore, Kathy Qi Cai, Wensi Tao, Elizabeth R Smith and Xiang-Xi Xu

    Citation: BMC Developmental Biology 2013 13:39

    Content type: Research article

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  35. It has been proven that c-kit is crucial for proliferation, migration, survival and maturation of spermatogenic cells. A periodic expression of c-kit is observed from primordial germ cells (PGCs) to spermatogenet...

    Authors: Lei Zhang, Jiangjing Tang, Christopher J Haines, Huai Feng, Liangxue Lai, Xiaoming Teng and Yibing Han

    Citation: BMC Developmental Biology 2013 13:38

    Content type: Research article

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  36. The myotome is the primitive skeletal muscle that forms within the embryonic metameric body wall. It can be subdivided into an epaxial and hypaxial domain. It has been shown that the formation of the epaxial m...

    Authors: Qin Pu, Aisha Abduelmula, Maryna Masyuk, Carsten Theiss, Dieter Schwandulla, Michael Hans, Ketan Patel, Beate Brand-Saberi and Ruijin Huang

    Citation: BMC Developmental Biology 2013 13:37

    Content type: Research article

    Published on:

    The Erratum to this article has been published in BMC Developmental Biology 2013 13:41

  37. Members of the vertebrate Numb family of cell fate determinants serve multiple functions throughout early embryogenesis, including an essential role in the development of the nervous system. The Numb proteins ...

    Authors: Frank Nieber, Marie Hedderich, Olaf Jahn, Tomas Pieler and Kristine A Henningfeld

    Citation: BMC Developmental Biology 2013 13:36

    Content type: Research article

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  38. Diacylglycerol kinase (DGK) is a key enzyme that regulates diacylglycerol (DG) turnover and is involved in a variety of physiological functions. The isoform DGKθ has a unique domain structure and is the sole m...

    Authors: Shuji Ueda, Becky Tu-Sekine, Minoru Yamanoue, Daniel M Raben and Yasuhito Shirai

    Citation: BMC Developmental Biology 2013 13:35

    Content type: Research article

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  39. Human amniotic fluid cells (hAFCs) may differentiate into multiple cell lineages and thus have a great potential to become a donor cell source for regenerative medicine. The ability of hAFCs to differentiate i...

    Authors: Dongmei Lai, Fangyuan Wang, Yifei Chen, Li Wang, Yanlin Wang and Weiwei Cheng

    Citation: BMC Developmental Biology 2013 13:34

    Content type: Research article

    Published on:

  40. Velo-cardio-facial syndrome/DiGeorge syndrome (VCFS/DGS) is caused by a 1.5-3 Mb microdeletion of chromosome 22q11.2, frequently referred to as 22q11.2 deletion syndrome (22q11DS). This region includes TBX1, a T-...

    Authors: Laina Freyer, Sonja Nowotschin, Melinda K Pirity, Antonio Baldini and Bernice E Morrow

    Citation: BMC Developmental Biology 2013 13:33

    Content type: Methodology article

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