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  1. The investigation of skeletal muscle development is of importance in stock farming and biomedicine. It is still ambiguous that whether animals are born with the full set of skeletal muscle fibers or if the num...

    Authors: Mingsen Li, Xingyu Zhou, Yaosheng Chen, Yaping Nie, Huaxing Huang, Hu Chen and Delin Mo

    Citation: BMC Developmental Biology 2015 15:42

    Content type: Research article

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  2. TALE-class homeodomain transcription factors Meis and Pbx play important roles in formation of the embryonic brain, eye, heart, cartilage or hematopoiesis. Loss-of-function studies of Pbx1, 2 and 3 and Meis1 d...

    Authors: Ondrej Machon, Jan Masek, Olga Machonova, Stefan Krauss and Zbynek Kozmik

    Citation: BMC Developmental Biology 2015 15:40

    Content type: Research article

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  3. Components of the limb musculoskeletal system have distinct mesoderm origins. Limb skeletal muscles originate from somites, while the skeleton and attachments (tendons and connective tissues) derive from limb ...

    Authors: Adeline Bourgeois, Joana Esteves de Lima, Benjamin Charvet, Koichi Kawakami, Sigmar Stricker and Delphine Duprez

    Citation: BMC Developmental Biology 2015 15:39

    Content type: Methodology article

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  4. The GATA-binding factor 6 (Gata6) gene encodes a zinc finger transcription factor that often functions as a key regulator of lineage specification during development. It is the earliest known marker of the primit...

    Authors: Laina Freyer, Christian Schröter, Néstor Saiz, Nadine Schrode, Sonja Nowotschin, Alfonso Martinez-Arias and Anna-Katerina Hadjantonakis

    Citation: BMC Developmental Biology 2015 15:38

    Content type: Methodology article

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  5. Primitive endoderm is a cell lineage segregated from the epiblast in the blastocyst and gives rise to parietal and visceral endoderm. Sox7 is a member of the SoxF gene family that is specifically expressed in pri...

    Authors: Masaki Kinoshita, Daisuke Shimosato, Mariko Yamane and Hitoshi Niwa

    Citation: BMC Developmental Biology 2015 15:37

    Content type: Research article

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  6. Development of the valves and septa of the heart depends on the formation and remodeling of the endocardial cushions in the atrioventricular canal and outflow tract. These cushions are populated by mesenchyme ...

    Authors: Ryan J. Coram, Samantha J. Stillwagon, Anuradha Guggilam, Michael W. Jenkins, Maurice S. Swanson and Andrea N. Ladd

    Citation: BMC Developmental Biology 2015 15:36

    Content type: Research article

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  7. Pluripotent cells are present in early embryos until the levels of the pluripotency regulator Oct4 drop at the beginning of somitogenesis. Elevating Oct4 levels in explanted post-pluripotent cells in vitro res...

    Authors: Constantinos Economou, Anestis Tsakiridis, Filip J. Wymeersch, Sabrina Gordon-Keylock, Robert E Dewhurst, Dawn Fisher, Alexander Medvinsky, Andrew JH Smith and Valerie Wilson

    Citation: BMC Developmental Biology 2015 15:35

    Content type: Research article

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  8. Sex determination in mammals requires expression of the Y-linked gene Sry in the bipotential genital ridges of the XY embryo. Even minor delay of the onset of Sry expression can result in XY sex reversal, highlig...

    Authors: Christian Larney, Timothy L. Bailey and Peter Koopman

    Citation: BMC Developmental Biology 2015 15:34

    Content type: Research article

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  9. In multiple vertebrate organisms, including chick, Xenopus, and zebrafish, Fibroblast Growth Factor (FGF) and Wnt signaling cooperate during formation of the otic placode. However, in the mouse, although FGF sign...

    Authors: Kevin D. Wright, Amanda A. Mahoney Rogers, Jian Zhang and Katherine Shim

    Citation: BMC Developmental Biology 2015 15:33

    Content type: Research article

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  10. Recent studies have identified epithelial stem and progenitor cell populations of the lung. We are just beginning to understand the mechanisms that regulate their homeostatic, regenerative and maladaptive beha...

    Authors: Matt L. Donne, Andrew J. Lechner and Jason R. Rock

    Citation: BMC Developmental Biology 2015 15:32

    Content type: Commentary

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  11. It remains unclear to what extent midgut rotation determines human intestinal topography and pathology. We reinvestigated the midgut during its looping and herniation phases of development, using novel 3D visu...

    Authors: Jelly HM Soffers, Jill PJM Hikspoors, Hayelom K. Mekonen, S. Eleonore Koehler and Wouter H. Lamers

    Citation: BMC Developmental Biology 2015 15:31

    Content type: Research article

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  12. Nearly half of all individuals with Down Syndrome (DS) have some type of congenital heart defect (CHD), suggesting that DS sensitizes to CHD but does not cause it. We used a common mouse model of DS, the Ts65D...

    Authors: Renita C. Polk, Peter Gergics, Jeffrey D. Steimle, Huiqing Li, Ivan P. Moskowitz, Sally A. Camper and Roger H. Reeves

    Citation: BMC Developmental Biology 2015 15:30

    Content type: Research article

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  13. Magnetic resonance imaging (MRI) has many advantages in the research of in vivo embryonic brain development, specifically its noninvasive aspects and ability to avoid skeletal interference. However, few studie...

    Authors: Zien Zhou, Zengai Chen, Jiehui Shan, Weiwei Ma, Lei Li, Jinyan Zu and Jianrong Xu

    Citation: BMC Developmental Biology 2015 15:29

    Content type: Research article

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  14. Haploinsufficiency of the FOXL2 transcription factor in humans causes Blepharophimosis/Ptosis/Epicanthus Inversus syndrome (BPES), characterized by eyelid anomalies and premature ovarian failure. Mice lacking Fox...

    Authors: Mara Marongiu, Loredana Marcia, Emanuele Pelosi, Mario Lovicu, Manila Deiana, Yonqing Zhang, Alessandro Puddu, Angela Loi, Manuela Uda, Antonino Forabosco, David Schlessinger and Laura Crisponi

    Citation: BMC Developmental Biology 2015 15:27

    Content type: Research article

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  15. During the fourth larval (L4) stage, vulval cells of C. elegans undergo extensive morphogenesis accompanied by changes in gene expression. This phase of vulval development, occurring after the well-studied induct...

    Authors: Darren Z. L. Mok, Paul W. Sternberg and Takao Inoue

    Citation: BMC Developmental Biology 2015 15:26

    Content type: Methodology article

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  16. MicroRNAs (miRNAs) are small noncoding RNAs that act as post-transcriptional regulators of gene targets. Accurate quantification of miRNA expression using validated internal controls should aid in the understa...

    Authors: Mahdi Mahdipour, Helena T.A. van Tol, Tom A.E. Stout and Bernard A.J. Roelen

    Citation: BMC Developmental Biology 2015 15:25

    Content type: Research article

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  17. Adult echinoderms can completely regenerate major parts of their central nervous system even after severe injuries. Even though this capacity has long been known, the molecular mechanisms that drive fast and c...

    Authors: Vladimir S Mashanov, Olga R Zueva and José E García-Arrarás

    Citation: BMC Developmental Biology 2015 15:24

    Content type: Research Article

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  18. HP1γ, a well-known regulator of gene expression, has been recently identified to be a target of Aurora A, a mitotic kinase which is important for both gametogenesis and embryogenesis. The purpose of this study...

    Authors: Phoebe H. Leonard, Adrienne Grzenda, Angela Mathison, Dean E. Morbeck, Jolene R. Fredrickson, Thiago M. de Assuncao, Trace Christensen, Jeffrey Salisbury, Ezequiel Calvo, Juan Iovanna, Charles C. Coddington, Raul Urrutia and Gwen Lomberk

    Citation: BMC Developmental Biology 2015 15:23

    Content type: Research article

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  19. Despite extensive knowledge on bivalve anatomy and development, the formation and differentiation of the mantle margin and its associated organs remain largely unclear. Bivalves from the family Pectinidae (sca...

    Authors: Jorge A. Audino, José Eduardo A. R. Marian, Andreas Wanninger and Sônia G. B. C. Lopes

    Citation: BMC Developmental Biology 2015 15:22

    Content type: Research article

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  20. The mouse embryonic mandible comprises two types of tooth primordia in the cheek region: progressive tooth primordia of prospective functional teeth and rudimentary tooth primordia in premolar region – MS and ...

    Authors: Katerina Lochovska, Renata Peterkova, Zuzana Pavlikova and Maria Hovorakova

    Citation: BMC Developmental Biology 2015 15:21

    Content type: Research article

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  21. Endothelial or epithelial cellular branching is vital in development and cancer progression; however, the molecular mechanisms of these processes are not clear. In Drosophila, terminal cell at the end of some tra...

    Authors: Matthew Man-Kin Wong, Ming-Fai Liu and Sung Kay Chiu

    Citation: BMC Developmental Biology 2015 15:20

    Content type: Research article

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  22. The ability to visualise the expression of individual genes in situ is an invaluable tool for developmental and evolutionary biologists; it allows for the characterisation of gene function, gene regulation and th...

    Authors: Jennifer Hohagen, Ines Herlitze and Daniel John Jackson

    Citation: BMC Developmental Biology 2015 15:19

    Content type: Methodology article

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  23. The developing eye receives blood supply from two vascular systems, the intraocular hyaloid system and the superficial choroidal vessels. In zebrafish, a highly stereotypic and simple set of vessels develops o...

    Authors: Rivka Kaufman, Omri Weiss, Meyrav Sebbagh, Revital Ravid, Liron Gibbs-Bar, Karina Yaniv and Adi Inbal

    Citation: BMC Developmental Biology 2015 15:18

    Content type: Research article

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  24. Marsupials such as the tammar wallaby (M.Eugenii) have a short gestation (29.3 days) and at birth the altricial young resembles a fetus, and the major development occurs postnatally while the young remains in the...

    Authors: Vengamanaidu Modepalli, Lyn A Hinds, Julie A Sharp, Christophe Lefevre and Kevin R Nicholas

    Citation: BMC Developmental Biology 2015 15:16

    Content type: Research article

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  25. There is increasing evidence of a pivotal role for regulated mRNA translation in control of developmental cell fate transitions. Physiological and pathological stem and progenitor cell self-renewal is maintain...

    Authors: Angus M MacNicol, Linda L Hardy, Horace J Spencer and Melanie C MacNicol

    Citation: BMC Developmental Biology 2015 15:15

    Content type: Research article

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  26. Human dental pulp represents a suitable alternative source of stem cells for the purpose of cell-based therapies in regenerative medicine, because it is relatively easy to obtain it, using low invasive procedu...

    Authors: Alessandra Pisciotta, Gianluca Carnevale, Simona Meloni, Massimo Riccio, Sara De Biasi, Lara Gibellini, Adriano Ferrari, Giacomo Bruzzesi and Anto De Pol

    Citation: BMC Developmental Biology 2015 15:14

    Content type: Research article

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  27. In mammals, maternal differentially methylated regions (DMRs) acquire DNA methylation during the postnatal growth stage of oogenesis, with paternal DMRs acquiring DNA methylation in the perinatal prospermatago...

    Authors: Alan M O’Doherty, David A Magee, Lynee C O’Shea, Niamh Forde, Marijke E Beltman, Solomon Mamo and Trudee Fair

    Citation: BMC Developmental Biology 2015 15:13

    Content type: Research article

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  28. Central American crater lake cichlid fish of the Midas species complex (Amphilophus spp.) are a model system for sympatric speciation and fast ecological diversification and specialization. Midas cichlids have be...

    Authors: Claudius F Kratochwil, Maggie M Sefton and Axel Meyer

    Citation: BMC Developmental Biology 2015 15:12

    Content type: Research article

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  29. Tissue fixation is crucial for preserving the morphology of biological structures and cytological details to prevent postmortem degradation and autolysis. Improper fixation conditions could lead to artifacts a...

    Authors: Jing Nie, Simpla Mahato and Andrew C Zelhof

    Citation: BMC Developmental Biology 2015 15:10

    Content type: Methodology article

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  30. Primary cilia are essential for Hedgehog (Hh) signal transduction in vertebrates. Although the core components of the Hh pathway are highly conserved, the dependency on cilia in Hh signaling is considered to b...

    Authors: Takayoshi Yamamoto, Tatsuya Tsukahara, Tadashi Ishiguro, Haruo Hagiwara, Masanori Taira and Hiroyuki Takeda

    Citation: BMC Developmental Biology 2015 15:9

    Content type: Research article

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  31. Stem cells can respond to environmental and physiological inputs to adaptively remodel tissues. Little is known about whether stem cell niches are similarly responsive. The Drosophila ovary germline stem cell (GS...

    Authors: Alessandro Bonfini, Marian B Wilkin and Martin Baron

    Citation: BMC Developmental Biology 2015 15:8

    Content type: Research article

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  32. Alveoli, the milk-producing units of the mammary gland, are generated during pregnancy by collaboration of different epithelial cell types. We present the first analysis of transcriptional changes within the h...

    Authors: Duvini De Silva, Kamini Kunasegaran, Sujoy Ghosh and Alexandra M Pietersen

    Citation: BMC Developmental Biology 2015 15:7

    Content type: Research article

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  33. We have revealed that the type II diacylglycerol kinases (DGKs) δ, η and κ were expressed in the testis and ovary. However, these enzymes’ functions in the reproductive organs remain unknown.

    Authors: Takao Shionoya, Takako Usuki, Suguru Komenoi, Takeshi Isozaki, Hiromichi Sakai and Fumio Sakane

    Citation: BMC Developmental Biology 2015 15:6

    Content type: Research article

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  34. The editors of BMC Developmental Biology would like to thank all our reviewers who have contributed to the journal in Volume 14 (2014).

    Authors: Philippa K Harris

    Citation: BMC Developmental Biology 2015 15:5

    Content type: Reviewer acknowledgement

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  35. In society, there is a clear need to improve the success rate of techniques to restore fertility. Therefore a deeper knowledge of the dynamics of the complex molecular environment that regulates human gametoge...

    Authors: A Marijne Heeren, Liesbeth van Iperen, Daniëlle B Klootwijk, Ana de Melo Bernardo, Matthias S Roost, Maria M Gomes Fernandes, Leonie A Louwe, Carina G Hilders, Frans M Helmerhorst, Lucette A J van der Westerlaken and Susana M Chuva de Sousa Lopes

    Citation: BMC Developmental Biology 2015 15:4

    Content type: Research article

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  36. Dietary interventions during pregnancy alter offspring fitness. We have shown mouse maternal low protein diet fed exclusively for the preimplantation period (Emb-LPD) before return to normal protein diet (NPD)...

    Authors: Congshan Sun, Oleg Denisenko, Bhavwanti Sheth, Andy Cox, Emma S Lucas, Neil R Smyth and Tom P Fleming

    Citation: BMC Developmental Biology 2015 15:3

    Content type: Research article

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  37. Planarians are an attractive model organism for studying stem cell-based regeneration due to their ability to replace all of their tissues from a population of adult stem cells. The molecular toolkit for plana...

    Authors: Kelly G Ross, Kerilyn C Omuro, Matthew R Taylor, Roma K Munday, Amy Hubert, Ryan S King and Ricardo M Zayas

    Citation: BMC Developmental Biology 2015 15:2

    Content type: Methodology article

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  38. Bioelectric phenomena have been found to exert influence on various developmental and regenerative processes. Little is known about their possible functions and the cellular mechanisms by which they might act ...

    Authors: Julia Krüger and Johannes Bohrmann

    Citation: BMC Developmental Biology 2015 15:1

    Content type: Research article

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  39. Zebrafish are able to regenerate many of its tissues and organs after damage. In amphibians this process is regulated by nerve fibres present at the site of injury, which have been proposed to release factors ...

    Authors: Mariana G Simões, Anabela Bensimon-Brito, Mariana Fonseca, Ana Farinho, Fábio Valério, Sara Sousa, Nuno Afonso, Anoop Kumar and Antonio Jacinto

    Citation: BMC Developmental Biology 2014 14:49

    Content type: Research article

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  40. Mapping of tissue structure at the cellular, circuit, and organ-wide scale is important for understanding physiological and biological functions. A bio-electrochemical technique known as CLARITY used for three...

    Authors: Hyunsu Lee, Jae-Hyung Park, Incheol Seo, Sun-Hyun Park and Shin Kim

    Citation: BMC Developmental Biology 2014 14:48

    Content type: Methodology article

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  41. Efforts to elucidate the cellular and molecular mechanisms of regeneration have required the application of methods to detect specific cell types and tissues in a growing cohort of experimental animal models. ...

    Authors: David J Forsthoefel, Forrest A Waters and Phillip A Newmark

    Citation: BMC Developmental Biology 2014 14:45

    Content type: Methodology article

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  42. Identification and characterization of molecular controls that regulate mammary stem and progenitor cell homeostasis are critical to our understanding of normal mammary gland development and its pathology.

    Authors: Gautam K Malhotra, Xiangshan Zhao, Emily Edwards, Janel L Kopp, Mayumi Naramura, Maike Sander, Hamid Band and Vimla Band

    Citation: BMC Developmental Biology 2014 14:47

    Content type: Research article

    Published on:

  43. In standard cell division, the cells undergo karyokinesis and then cytokinesis. Some cells, however, such as cardiomyocytes and hepatocytes, can produce binucleate cells by going through mitosis without cytoki...

    Authors: Kiichiro Taniguchi, Akihiko Kokuryo, Takao Imano, Ryunosuke Minami, Hideki Nakagoshi and Takashi Adachi-Yamada

    Citation: BMC Developmental Biology 2014 14:46

    Content type: Research article

    Published on:

  44. The development of the craniofacial skeleton from embryonic mesenchyme is a complex process that is not yet completely understood, particularly for intramembranous bones. This study investigates the developmen...

    Authors: Carolyn T Chang and Tamara Anne Franz-Odendaal

    Citation: BMC Developmental Biology 2014 14:44

    Content type: Research article

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  45. The mechanistic target of rapamycin complex1 (mTORC1) signaling pathway has been implicated in functions of multicellular processes, including cell growth and metabolism. Although recent reports showed that ma...

    Authors: Kentaro Hirose, Taishi Shiomi, Shunya Hozumi and Yutaka Kikuchi

    Citation: BMC Developmental Biology 2014 14:42

    Content type: Research article

    Published on:

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