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  1. Long non-coding RNAs (LncRNAs) have been identified to play important roles in epigenetic processes that underpin organogenesis. However, the role of LncRNAs in the regulation of transition from fetal to adult...

    Authors: Jue Wang, Zhimin Geng, Jiakan Weng, Longjie Shen, Ming Li, Xueli Cai, Chengchao Sun and Maoping Chu

    Citation: BMC Developmental Biology 2016 16:41

    Content type: Research article

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  2. Establishment of the left-right axis is important for positioning organs asymmetrically in the developing vertebrate-embryo. A number of factors like maternally deposited molecules have emerged essential in in...

    Authors: Kartik Gupta, Vijaya Satish Sekhar Pilli and Gopala Krishna Aradhyam

    Citation: BMC Developmental Biology 2016 16:39

    Content type: Research article

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  3. Because ribosomes are ubiquitously required for protein production, it was long assumed that any inherited defect in ribosome manufacture would be embryonically lethal. However, several human congenital diseas...

    Authors: Andrew Robson, Nick D. L. Owens, Susan J. Baserga, Mustafa K. Khokha and John N. Griffin

    Citation: BMC Developmental Biology 2016 16:38

    Content type: Research article

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  4. Increased apposition of the frontal and parietal bones of the skull during embryogenesis may be a risk factor for the subsequent development of premature skull fusion, or craniosynostosis. Human craniosynostos...

    Authors: Stephen J. Goldie, Benedicta D. Arhatari, Peter Anderson, Alana Auden, Darren D. Partridge, Stephen M. Jane and Sebastian Dworkin

    Citation: BMC Developmental Biology 2016 16:37

    Content type: Research article

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  5. Successful development of iSCNT (interspecies somatic cell nuclear transfer) embryos depends on complex interactions between ooplasmic and nuclear components, which can be compromised by genetic divergence. Tr...

    Authors: L. Antonio González-Grajales, Laura A. Favetta, W. Allan King and Gabriela F. Mastromonaco

    Citation: BMC Developmental Biology 2016 16:36

    Content type: Research article

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  6. The multicellular volvocine alga Pleodorina is intermediate in organismal complexity between its unicellular relative, Chlamydomonas, and its multicellular relative, Volvox, which shows complete division of labor...

    Authors: Stephanie Höhn and Armin Hallmann

    Citation: BMC Developmental Biology 2016 16:35

    Content type: Research article

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  7. Bone morphogenetic protein (BMP) signalling has emerged as a fundamental pathway in endothelial cell biology and deregulation of this pathway is implicated in several vascular disorders. BMP signalling output ...

    Authors: Karen Beets, Michael W. Staring, Nathan Criem, Elke Maas, Niels Schellinx, Susana M. Chuva de Sousa Lopes, Lieve Umans and An Zwijsen

    Citation: BMC Developmental Biology 2016 16:34

    Content type: Research article

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  8. Nuclear receptors are a highly conserved set of ligand binding transcription factors, with essential roles regulating aspects of vertebrate and invertebrate biology alike. Current understanding of nuclear rece...

    Authors: Susanne Vogeler, Tim P. Bean, Brett P. Lyons and Tamara S. Galloway

    Citation: BMC Developmental Biology 2016 16:33

    Content type: Research article

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  9. Nuclear Factor-Kappa B (NF-kB) is a family of transcription factors that are important in embryonic development, inflammation, epithelial-to-mesenchymal transition and cancer. The 65 kDa RelA subunit is the ma...

    Authors: Talha Ijaz, Maki Wakamiya, Hong Sun, Adrian Recinos III, Ronald G. Tilton and Allan R. Brasier

    Citation: BMC Developmental Biology 2016 16:32

    Content type: Methodology article

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  10. HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 (HACE1) regulates a wide variety of cellular processes. It has been shown that one of the targets of HACE1 is the GTP-bound form of the s...

    Authors: Akira Iimura, Fuhito Yamazaki, Toshiyasu Suzuki, Tatsuya Endo, Eisuke Nishida and Morioh Kusakabe

    Citation: BMC Developmental Biology 2016 16:31

    Content type: Research article

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  11. Wnt11 is a member of the Wnt family of secreted signals controlling the early steps in ureteric bud (UB) branching. Due to the reported lethality of Wnt11 knockout embryos in utero, its role in later mammalian ki...

    Authors: Irina I. Nagy, Qi Xu, Florence Naillat, Nsrein Ali, Ilkka Miinalainen, Anatoly Samoylenko and Seppo J. Vainio

    Citation: BMC Developmental Biology 2016 16:30

    Content type: Research article

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  12. Authors: Daniel Silberschmidt, Alina Rodriguez-Mallon, Prathiba Mithboakar, Gaetano Calì, Elena Amendola, Remo Sanges, Mariastella Zannini, Marzia Scarfò, Pasquale De Luca, Lucio Nitsch, Roberto Di Lauro and Mario De Felice

    Citation: BMC Developmental Biology 2016 16:29

    Content type: Erratum

    Published on:

    The original article was published in BMC Developmental Biology 2011 11:9

  13. Left-right (LR) organ asymmetries are a common feature of metazoan animals. In many cases, laterality is established by a conserved asymmetric Nodal signaling cascade during embryogenesis. In most vertebrates,...

    Authors: Matthias Tisler, Franziska Wetzel, Sabrina Mantino, Stanislav Kremnyov, Thomas Thumberger, Axel Schweickert, Martin Blum and Philipp Vick

    Citation: BMC Developmental Biology 2016 16:28

    Content type: Research article

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  14. The Hedgehog (HH) signalling pathway regulates cardiomyogenesis in vivo and in differentiating P19 embryonal carcinoma (EC) cells, a mouse embryonic stem (mES) cell model. To further assess the transcriptional...

    Authors: Joel Vincent Fair, Anastassia Voronova, Neven Bosiljcic, Rashida Rajgara, Alexandre Blais and Ilona Sylvia Skerjanc

    Citation: BMC Developmental Biology 2016 16:27

    Content type: Research article

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  15. Myostatin (MSTN) encodes a negative regulator of skeletal muscle mass that might have applications for promoting muscle growth in livestock. In this study, we aimed to test whether tar...

    Authors: Baoli Yu, Rui Lu, Yuguo Yuan, Ting Zhang, Shaozheng Song, Zhengqiang Qi, Bin Shao, Mengmin Zhu, Fei Mi and Yong Cheng

    Citation: BMC Developmental Biology 2016 16:26

    Content type: Research article

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  16. There is a gap in knowledge regarding the cardiovascular system in fish conjoined twins, and regarding the cardiovascular morphogenesis of conjoined twins in general. We examined the cardiovascular system in a...

    Authors: Per Gunnar Fjelldal, Monica F. Solberg, Tom Hansen, Tone Vågseth, Kevin Alan Glover and Harald Kryvi

    Citation: BMC Developmental Biology 2016 16:25

    Content type: Research article

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  17. Ion-transport mechanisms and gap junctions are known to cooperate in creating bioelectric phenomena, like pH gradients, voltage gradients and ion fluxes within single cells, tissues, organs, and whole organism...

    Authors: Julia Lautemann and Johannes Bohrmann

    Citation: BMC Developmental Biology 2016 16:24

    Content type: Research article

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  18. Birt-Hogg-Dubé syndrome (BHD) is a dominantly inherited familial cancer syndrome characterised by the development of benign skin fibrofolliculomas, multiple lung and kidney cysts, spontaneous pneumothorax and ...

    Authors: Emma J. Kenyon, Monique N. H. Luijten, Harmeet Gill, Nan Li, Matthew Rawlings, James C. Bull, Yavor Hadzhiev, Maurice A. M. van Steensel, Eamonn Maher and Ferenc Mueller

    Citation: BMC Developmental Biology 2016 16:23

    Content type: Research article

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  19. Selective plane illumination microscopy (SPIM a type of light-sheet microscopy) involves focusing a thin sheet of laser light through a specimen at right angles to the objective lens. As only the thin section ...

    Authors: Johannes Girstmair, Anne Zakrzewski, François Lapraz, Mette Handberg-Thorsager, Pavel Tomancak, Peter Gabriel Pitrone, Fraser Simpson and Maximilian J. Telford

    Citation: BMC Developmental Biology 2016 16:22

    Content type: Methodology article

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  20. Current knowledge of the human fetal and embryonic development relies on early descriptive studies of humans and from experimental studies of laboratory animals and embryos. Taking the upper extremity as an ex...

    Authors: Inga Langner, Thomas Stahnke, Oliver Stachs, Tobias Lindner, Jens-Peter Kühn, Simon Kim, Andreas Wree and Soenke Langner

    Citation: BMC Developmental Biology 2016 16:21

    Content type: Research article

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  21. Flatworms possess pluripotent stem cells that can give rise to all cell types, which allows them to restore lost body parts after injury or amputation. This makes flatworms excellent model systems for studying...

    Authors: Birgit Lengerer, Elise Hennebert, Patrick Flammang, Willi Salvenmoser and Peter Ladurner

    Citation: BMC Developmental Biology 2016 16:20

    Content type: Research article

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  22. Definitive endoderm (DE) gives rise to the respiratory apparatus and digestive tract. Sox17 and Cxcr4 are useful markers of the DE. Previously, we identified a novel DE marker, Decay accelerating factor 1(Daf1...

    Authors: Soichiro Ogaki, Hisayoshi Omori, Mayu Morooka, Nobuaki Shiraki, Seiichi Ishida and Shoen Kume

    Citation: BMC Developmental Biology 2016 16:19

    Content type: Research article

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  23. The pituitary gland is a highly vascularized tissue that requires coordinated interactions between the neural ectoderm, oral ectoderm, and head mesenchyme during development for proper physiological function. ...

    Authors: Shannon W. Davis, Amanda H. Mortensen, Jessica L. Keisler, Amanda L. Zacharias, Philip J. Gage, Ken-ichi Yamamura and Sally A. Camper

    Citation: BMC Developmental Biology 2016 16:16

    Content type: Research article

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  24. Insect metamorphosis relies on temporal and spatial cues that are precisely controlled. Previous studies in Drosophila have shown that untimely activation of genes that are essential to metamorphosis results in g...

    Authors: Kimberly Regna, Peri T. Kurshan, Benjamin N. Harwood, Adam M. Jenkins, Chao-Qiang Lai, Marc A.T. Muskavitch, Alan S. Kopin and Isabelle Draper

    Citation: BMC Developmental Biology 2016 16:15

    Content type: Research article

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  25. Wnt5a and Mrfzb1 genes are involved in the regulation of tooth size, and their expression levels are similar to that of Bmp7 during morphogenesis, including during the cap and early be...

    Authors: Kazuyuki Saito, Katsu Takahashi, Masakazu Asahara, Honoka Kiso, Yumiko Togo, Hiroko Tsukamoto, Boyen Huang, Manabu Sugai, Akira Shimizu, Masaharu Motokawa, Harold C. Slavkin and Kazuhisa Bessho

    Citation: BMC Developmental Biology 2016 16:14

    Content type: Research article

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  26. During early development of the nervous system, gene expression patterns are known to vary widely depending on the specific developmental trajectories of different structures. Observable changes in gene expres...

    Authors: Jimena Monzón-Sandoval, Atahualpa Castillo-Morales, Araxi O. Urrutia and Humberto Gutierrez

    Citation: BMC Developmental Biology 2016 16:13

    Content type: Research article

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  27. The contribution of programmed cell death (PCD) to muscle wasting disorders remains a matter of debate. Drosophila melanogaster metamorphosis offers the opportunity to study muscle cell death in the context of de...

    Authors: Yadav Kuleesha, Wee Choo Puah and Martin Wasser

    Citation: BMC Developmental Biology 2016 16:12

    Content type: Research article

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  28. We previously reported that the pluripotent stem cells can differentiate into cardiomyocytes (CMs) by co-culture with neonatal CMs (NCMs) in vitro. However, the involving mechanism is not clear.

    Authors: Dongbo Ou, Qi Wang, Yanjin Huang, Di Zeng, Ting Wei, Lu Ding, Xiaoli Li, Qiangsun Zheng and Yan Jin

    Citation: BMC Developmental Biology 2016 16:11

    Content type: Research article

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  29. Detailed descriptions of the early development of parasitic nematodes are seldom available. The embryonic development of the plant-parasitic nematode Meloidogyne incognita was studied, focusing on the early event...

    Authors: Alejandro Calderón-Urrea, Bartel Vanholme, Sandra Vangestel, Saben M. Kane, Abdellatif Bahaji, Khavong Pha, Miguel Garcia, Alyssa Snider and Godelieve Gheysen

    Citation: BMC Developmental Biology 2016 16:10

    Content type: Research article

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  30. Mollusca is the second largest phylum in nature. The shell of molluscs is a remarkable example of a natural composite biomaterial. Biomineralization and how it affects mollusks is a popular research topic. The...

    Authors: Mi Zhao, Yu Shi, Maoxian He, Xiande Huang and Qi Wang

    Citation: BMC Developmental Biology 2016 16:9

    Content type: Research article

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  31. It has been suggested that the ectopic expression of PDX1, a dominant pancreatic transcription factor, plays a critical role in the developmental programming of the pancreas even from cells of unrelated tissue...

    Authors: Shruti Balaji, Yu Zhou, Anasuya Ganguly, Emmanuel C. Opara and Shay Soker

    Citation: BMC Developmental Biology 2016 16:8

    Content type: Research article

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  32. Akt (PKB) is a serine threonine protein kinase downstream of the phosphoinositide 3-kinase (PI3K) pathway. In mammals, Akt is ubiquitously expressed and is associated with regulation of cellular proliferation,...

    Authors: T. Harshani Peiris, Daniel Ramirez, Paul G. Barghouth and Néstor J. Oviedo

    Citation: BMC Developmental Biology 2016 16:7

    Content type: Research article

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  33. Time-lapse imaging has proven highly valuable for studying development, yielding data of much finer resolution than traditional “still-shot” studies and allowing direct examination of tissue and cell dynamics....

    Authors: Eduardo E. Zattara, Kate W. Turlington and Alexandra E. Bely

    Citation: BMC Developmental Biology 2016 16:6

    Content type: Methodology article

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  34. Microenvironments called niches maintain resident stem cell populations by balancing self-renewal with differentiation, but the genetic regulation of this process is unclear. The niche of the Drosophila testis...

    Authors: Amanda J. Monahan and Michelle Starz-Gaiano

    Citation: BMC Developmental Biology 2016 16:5

    Content type: Research article

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  35. The Hedgehog (Hh) signaling pathway, acting through three homologous transcription factors (GLI1, GLI2, GLI3) in vertebrates, plays multiple roles in embryonic organ development and adult tissue homeostasis. A...

    Authors: Katherine Gurdziel, Kyle R. Vogt, Gary Schneider, Neil Richards and Deborah L. Gumucio

    Citation: BMC Developmental Biology 2016 16:4

    Content type: Research article

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  36. The correct evaluation of mineralization is fundamental for the study of skeletal development, maintenance, and regeneration. Current methods to visualize mineralized tissue in zebrafish rely on: 1) fixed spec...

    Authors: A. Bensimon-Brito, J. Cardeira, G. Dionísio, A. Huysseune, M. L. Cancela and P. E. Witten

    Citation: BMC Developmental Biology 2016 16:2

    Content type: Methodology article

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  37. Bone morphogenetic proteins regulate multiple processes in embryonic development, including early dorso-ventral patterning and neural crest development. BMPs activate heteromeric receptor complexes consisting ...

    Authors: Carolin Schille, Jens Heller and Alexandra Schambony

    Citation: BMC Developmental Biology 2016 16:1

    Content type: Research article

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  38. It has been found that microRNAs (miRNAs) play important roles in the regulation of tooth development, and most likely increase the complexity of the genetic network, thus lead to greater complexity of teeth. ...

    Authors: Ang Li, Ye Li, Tieli Song, Fu Wang, Dayong Liu, Zhipeng Fan, San Cheng, Chunmei Zhang, Jinsong Wang, Junqi He and Songlin Wang

    Citation: BMC Developmental Biology 2015 15:51

    Content type: Research article

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  39. The vertebrate heart consists of three cell layers: the innermost endothelium, the contractile myocardium and the outermost epicardium. The epicardium is vital for heart development and function, and forms fro...

    Authors: Monica S. Yue, Jessica S. Plavicki, Xin-yi Li, Richard E. Peterson and Warren Heideman

    Citation: BMC Developmental Biology 2015 15:50

    Content type: Methodology article

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  40. This study describes the generation and analysis of the transcriptional profile of bovine inner cell mass (ICM) and trophectoderm (TE), obtained from in vivo developed embryos by using a bovine-embryo specific...

    Authors: S. M. Hosseini, I. Dufort, J. Caballero, F. Moulavi, H. R. Ghanaei and M. A. Sirard

    Citation: BMC Developmental Biology 2015 15:49

    Content type: Research article

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  41. Salamanders regenerate their tails after amputation anywhere along their length. How the system faithfully reconstitutes the original number of segments and length is not yet known.

    Authors: Carr D. Vincent, Fabian Rost, Wouter Masselink, Lutz Brusch and Elly M. Tanaka

    Citation: BMC Developmental Biology 2015 15:48

    Content type: Research article

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  42. Biliary atresia (BA) is a human infant disease with inflammatory fibrous obstructions in the bile ducts and is the most common cause for pediatric liver transplantation. In contrast, the sea lamprey undergoes ...

    Authors: Yu-Wen Chung-Davidson, Chu-Yin Yeh, Ugo Bussy, Ke Li, Peter J. Davidson, Kaben G. Nanlohy, C. Titus Brown, Steven Whyard and Weiming Li

    Citation: BMC Developmental Biology 2015 15:47

    Content type: Research article

    Published on:

  43. Super-resolution fluorescence microscopy performed via 3D structured illumination microscopy (3D-SIM) is well established on flat, adherent cells. However, blastomeres of mammalian embryos are non-adherent, ro...

    Authors: Jens Popken, Maik Dahlhoff, Tuna Guengoer, Eckhard Wolf and Valeri Zakhartchenko

    Citation: BMC Developmental Biology 2015 15:46

    Content type: Methodology article

    Published on:

  44. The endogenous ability to dedifferentiate, re-pattern, and re-differentiate adult cells to repair or replace damaged or missing structures is exclusive to only a few tetrapod species. The Mexican axolotl is on...

    Authors: Catherine D. McCusker, Antony Athippozhy, Carlos Diaz-Castillo, Charless Fowlkes, David M. Gardiner and S. Randal Voss

    Citation: BMC Developmental Biology 2015 15:45

    Content type: Research article

    Published on:

  45. Acute kidney injury in mammals, which is caused by cardiovascular diseases or the administration of antibiotics with nephrotoxic side-effects is a life-threatening disease, since loss of nephrons is irreversib...

    Authors: Beate Hoppe, Stefan Pietsch, Martin Franke, Sven Engel, Marco Groth, Matthias Platzer and Christoph Englert

    Citation: BMC Developmental Biology 2015 15:43

    Content type: Research article

    Published on:

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