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Fig. 4 | BMC Developmental Biology

Fig. 4

From: Natriuretic peptides and Forkhead O transcription factors act in a cooperative manner to promote cardiomyocyte cell cycle re-entry in the postnatal mouse heart

Fig. 4

Transient elevation of FOXO phosphorylation in neonatal mouse heart ventricles. a Western blot showing levels of FOXO1 and FOXO3 proteins, phosphorylated FOXO1 (p-FOXO1- Ser 256), and phosphorylated FOXO3 (p-FOXO3- Ser 318/321) in the tissue lysates from P1 to P10 heart ventricles. b Quantification of the ratio of p-FOXO1/p-FOXO3 to total FOXO1/FOXO3 (p-FOXO/FOXO) in heart ventricles. c Correlation of transient elevation of FOXO phosphorylation in heart ventricles with the rapid increase in cardiomyocyte cell cycle activity (EdU+ CM) in P3 hearts. P value was calculated using one-way ANOVA. *P < 0.05; **P < 0.01

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