Fig. 4
From: Generation and identification of a conditional knockout allele for the PSMD11 gene in mice
Constitutive ablation of PSMD11 leads to early embryonic lethality (PSMD11−/−) and growth retardation (PSMD11+/−) in mice. a Methods to generate PSMD11 constitutive KO mice. b Genotyping of E7.5–8.5 embryos from intercrossing between PSMD11+/− heterozygous mice. The 643 bp band indicate the exon 5 deleted allele of PSMD11 (PSMD11∆). c Representative Smaller body size of PSMD11+/− mice compared with WT littermates. d Growth curve of PSMD11+/− mice (n = 9) and age- and sex-matched male and female WT littermates (n = 9), **P < 0.01, *P < 0.05. e Representative image of E7.5–8.5 embryos of mice under stereomicroscope. f Representative HE images of E7.5–8.5 WT and PSMD11+/− embryos of mice. g and h Representative images of Arcturus Histogene™ staining and Laser Capture Microdissected tissues of E7.5–8.5 embryos of mice