Fig. 11

Schematic representation of correlations between pH_i, V_mem, bMF and MT. The different FC types in S10b (cf. Figure 1) are symbolised by white hexagons, and the applied inhibitors by orange circles. The organisation of bMF in FC is symbolised by red lines (parallel orientation: d-v or oblique; dotted: disintegration) or by red asterisks in hexagons (dark red: condensation; light red: condensation and disintegration). The organisation of MT in FC is symbolised by green lines (parallel orientation: a-p; thick line: thickening) or by green circles in hexagons (loss of parallel orientation and partial disintegration). Dotted arrows indicate changes of pH_i (relative acidification or alkalisation; left margin) and changes of V_mem (relative hyperpolarisation or depolarisation; bottom margin) relative to the control state (centre). The correlations between pH_i, V_mem, bMF and MT observed in different FC types during S10b are in line with the correlations resulting from the inhibition of Na⁺/H⁺-exchangers and Na⁺-channels (amiloride), V-ATPases (bafilomycin), ATP-sensitive K⁺-channels (glibenclamide), voltage-dependent L-type Ca²⁺-channels (verapamil), Cl⁻-channels (9-anthroic acid) or Na⁺/K⁺/2Cl⁻-cotransporters (furosemide). While alkalisation and/or hyperpolarisation stabilises the parallel transversal alignment of bMF, acidification leads to increasing disorder and to condensations of bMF. On the other hand, acidification as well as hyperpolarisation stabilises the longitudinal orientation of MT, whereas alkalisation leads to loss of this arrangement and to partial disintegration