Table 1 Embryonic lethality of Notch1[12f/12f] after backcrossing to C57BL/6 J
From: A modifier in the 129S2/SvPasCrl genome is responsible for the viability of Notch1[12f/12f] mice
Cross | Intercross Pairs (Litters) | Notch1 [+/+] | Notch1 [12f/+] | Notch1 [12f/12f] | Chi-Squared Test |
|---|---|---|---|---|---|
Toronto Notch1[12f/+] X Toronto Notch1[12f/+] | 5 (8) | 18 | 36 | 14 | Â |
Expected ratio |  | 17 | 34 | 17 | P = 0.7 |
Backcrossed 11 generations (1st cohort) | 19 (65) | 103 | 178 | 13 | Â |
C57BL/6 J.Notch1[12f/+] X C57BL/6 J.Notch1[12f/+] | |||||
Expected ratio |  | 74 | 147 | 74 | P = 1.57e-15 |
Backcrossed 15 generations (2nd cohort) | 9 (9) | 19 | 33 | 2 | Â |
C57BL/6 J.Notch1[12f/+] X C57BL/6 J.Notch1[12f/+] | |||||
Expected ratio |  | 14 | 27 | 14 | P = 0.0013 |