Fig. 4
From: Role of PRY-1/Axin in heterochronic miRNA-mediated seam cell development
DE miRNAs and their predicted target genes in pry-1(mu38) are mostly linked to heterochronic development. (a) Enrichment analysis of potential targets of DE miRNAs using GO-terms associated with biological processes. AÂ significant number of genes (29-fold enrichment) are linked to heterochronic development (colour coded in orange). (b) Venn diagram showing the overlap between previously reported protein-coding DE genes (2,660 genes, [25]) and predicted targets of DE miRNAs identified by Targetscan (435 genes, this study) in pry-1(mu38) animals. Further analysis revealed that 435 potential targets are shared between DE miRNAs (36 by lin-4, 115 by miR-48, 115 by miR-84, 36 by miR-237, 115 by miR-241, and 102 by miR-246). A total 111 genes are common between the two data sets, a number that is statistically significant based on the hypergeometric test. (c) Tissue-enrichment analysis of the common set of genes (111) revealed third highest fold enrichment in hypodermal syncytium cells (colour coded in orange)