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Fig. 3 | BMC Developmental Biology

Fig. 3

From: The asymmetric cell division machinery in the spiral-cleaving egg and embryo of the marine annelid Platynereis dumerilii

Fig. 3

ACD components establishing cortical domains. a Schematic drawing illustrating localization of ACD components establishing two opposing asymmetric cortical domains within one cell based upon previous work including C. elegans. a‛ Detail of (a) illustrating the juxtaposed cortical ACD complexes. Anterior Par network proteins (Cdc42, Par3, Par6, and aPKC) form an anterior cortical complex (orange). Posterior network Par proteins (L(2)gl, and Par1) associate to form a posterior cortical complex (green). Arrows indicate assembly of cortical complexes from individual ACD components. Both complexes mutually repress each other through reciprocal phosphorylation of components. b, c Transcriptional profiles of cortical domain components during early development of P. dumerilii based on RNA-seq: x-axis shows time in hours post fertilization (hpf), y-axis shows median level of transcripts in fragments per kilobase per million reads (FPKM) from two independent biological replicates (Additional file 5). Expression levels for most components are high at 2 hpf and decrease during later stages. b Expression profiles of anterior cortical domain components. c Expression profiles of posterior cortical domain components. For error bars see Additional file 9

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