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Fig. 7 | BMC Developmental Biology

Fig. 7

From: Muscleblind-like 1 is required for normal heart valve development in vivo

Fig. 7

Mbnl1 E∆3/∆E3 mice exhibit ostium secundum atrial septal defects. a The heart of a one year-old adult Mbnl1 ∆E3/∆E3 mouse is shown with the atrial appendages removed. Patency of the foramen ovale is demonstrated by the unobstructed passage of a coarse bristle. b Excision of the atrial septum from adult hearts shows failure of the foramen ovale to close in some Mbnl1 ∆E3/∆E3 mice (left), while the foramen ovale is closed but enlarged in others (right). Representative images of the wild type and patent Mbnl1 ∆E3/∆E3 foramen ovales shown are from 10 month-old mice; the image of the closed, but enlarged, foramen ovale is from a 2.5-month old Mbnl1 ∆E3/∆E3 mouse. Compared to a wild type counterpart (c), the foramen ovale (bracketed by the green lines) is enlarged in an E19.5 Mbnl1 ∆E3/∆E3 heart (d) as shown in close-ups of coronal sections stained with Masson’s trichrome. SS = septum secundum, FV = flap valve, FO = foramen ovale

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