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Fig. 6 | BMC Developmental Biology

Fig. 6

From: Conservation analysis of sequences flanking the testis-determining gene Sry in 17 mammalian species

Fig. 6

TF binding motifs are locally enriched in non-conserved Sry flanking sequences. Motifs are positioned at the centres of the windows in which they were found, and are colour-coded to indicate presence in mouse and/or human. The origin (labelled as 0) is 7 bp downstream of the annotated human TSS (hg19), and corresponds to a conserved SP factor motif. Additional file 5: Table S2 lists the positions of the origin in other species. Motifs were included in this figure only if they were detected in at least eight species, and their presence had an E-value no greater than 1 (with two exceptions, see below). a Sites found by CentriMo in 600 bp sequences from 17 species (Additional file 7, wherein position +200 corresponds to the figure origin; Additional file 8), with the SPCI indicated by a shaded blue box. NR4A2 is included for biological relevance, despite an E-value of 6. b Additional sites detected by FIMO in corresponding 100 bp windows of 10 kb sequences from 13 species (Additional file 10). NR2F6 is included for biological relevance, despite its presence in only seven species

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