Figure 6
From: Wnt4 is not sufficient to induce lobuloalveolar mammary development
Wnt16 expression is induced by Wnt4. (A) Comparison of Wnt signaling-related gene expression profiles for virgin and pregnant (5.5 d.p) glands (upper panel) or for virgin and doxycycline-administered tet-Wnt4/MMTV-rtTA glands (lower panel). Vertical red lines indicate an arbitrary cut-off for significance (2 fold) up- or down-regulation, and the horizontal blue line denotes a significance p value of 0.001. (B) Wnt16 expression is induced by canonical Wnt signaling agonists in HC11 cells. HC11 cells were either transduced with Wnt signaling agonists encoding retroviruses, or were treated with conditioned media ± Wnt3a. Wnt16 mRNA amounts was measured using qPCR.