Figure 1
From: Coordinate regulation of DNA methyltransferase expression during oogenesis
Developmental expression profiles of Dnmt3a , Dnmt3b , and Dnmt3L during postnatal oogenesis. QRT-PCR was used to determine the expression profile of a) Dnmt3a (light grey bars) b) Dnmt3b (cross hatch bars) and c) Dnmt3L (dark grey bars) in postnatal oocytes. Relative expression values obtained were normalized to the level of rabbit α-globin expression for each sample and were calibrated to the MII oocyte expression value. Representative results from one of the two independent experiments performed are plotted (see Additional file 2 for the second replicate). While the relative abundance of the transcripts varied for each of the timepoints, overall Dnmt3a, Dnmt3b and Dnmt3L expression increased with oocyte growth and peaked in 25 dpp oocytes for each enzyme. Results are presented as mean ± SD. * indicates significance of p < 0.05; ** indicates significance of p < 0.01.