C-type natriuretic peptide regulates endochondral bone growth through p38 MAP kinase-dependent and – independent pathways

Agoston, Hanga; Khan, Sameena; James, Claudine G; Gillespie, J Ryan; Serra, Rosa; Stanton, Lee-Anne; Beier, Frank

doi:10.1186/1471-213X-7-18

Table 1 Genes showing 2-fold or greater changes in resting/proliferating zone

From: C-type natriuretic peptide regulates endochondral bone growth through p38 MAP kinase-dependent and – independent pathways

Gene Name	Gene Description	Fold Change (CNP/Control)
Spock3	sparc/osteonectin, cwcv and kazal-like domains proteoglycan 3	2.76
Il15	interleukin 15	2.73
Mgst2	microsomal glutathione S-transferase 2	2.60
Alcam	activated leukocyte cell adhesion molecule	2.52
Tec	cytoplasmic tyrosine kinase, Dscr28C related (Drosophila)	2.27
Aard	alanine and arginine rich domain containing protein	2.24
Tnfsf11	tumor necrosis factor (ligand) superfamily, member 11	2.18
Vegfc	vascular endothelial growth factor C	2.18
Senp8	SUMO/sentrin specific protease family member 8	2.09
Pde4b	phosphodiesterase 4B, cAMP specific	2.02
Gcnt2	glucosaminyl (N-acetyl) transferase 2, I-branching enzyme	0.18
Cidea	cell death-inducing DNA fragmentation factor, alpha subunit-like	0.24
Frzb	frizzled-related protein	0.28
F5	coagulation factor V	0.31
Car8	carbonic anhydrase 8	0.32
Ibsp	integrin binding sialoprotein	0.34
Lifr	leukemia inhibitory factor receptor	0.36
Col10a1	procollagen, type X, alpha 1	0.37
Lepr	leptin receptor	0.37
Ibsp	integrin binding sialoprotein	0.38
Pthr1	parathyroid hormone receptor 1	0.38
Clcn7	chloride channel 7	0.41
Chd7	chromodomain helicase DNA binding protein 7	0.42
H2-DMa	histocompatibility 2, class II, locus DMa	0.42
Col13a1	procollagen, type XIII, alpha 1	0.42
Cntn1	contactin 1	0.43
Slc7a3	solute carrier family 7, member 3	0.44
Tm7sf1	transmembrane 7 superfamily member 1	0.45
Iqsec1	IQ motif and Sec7 domain 1	0.45
Pthlh	parathyroid hormone-like peptide	0.46
Pdzk3	PDZ domain containing 2	0.46
Tmie	transmembrane inner ear	0.47
Ifitm5	interferon induced transmembrane protein 5	0.47
Socs2	suppressor of cytokine signaling 2	0.47
Angptl2	angiopoietin-like 2	0.48
Capn6	calpain 6	0.48
Atp10d	ATPase, Class V, type 10D	0.48
Cald1	caldesmon 1	0.49
Phtf2	putative homeodomain transcription factor 2	0.50

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ISSN: 1471-213X

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