Characterization, developmental expression and evolutionary features of the huntingtin gene in the amphioxus Branchiostoma floridae

Table 2 HEAT repeat consensus sequence

	consensus		sequence
1	*H. sapiens*	HEAT_AAA	QKLLGIAMELFLLCSDDAESDVRMVADECLNKVIKALMD
	*B. floridae*	HEAT_AAA	PKFLGISMEMFLASCDDKESDVRMVADECLNRTVKMLLE
	*C. intestinalis*	HEAT_AAA	PGLLAVSVETLLQSCADDNADVRLNANECLNRLIKGLYE
2	*H. sapiens*	HEAT_AAA	RPYLVNLLPCLTRTSKRPEESVQETLAAAVPKIMASFGN
	*B. floridae*	HEAT_AAA	RPYVVNLLPCFNRICRRQEDAVQETLANSLKKTFPVLGS
	*C. intestinalis*	HEAT_AAA	RPYILNLLPCLCRISQREEDGVQETLGLSLVKIFKILGP
3	*H. sapiens*	HEAT_AAA	DNEIKVLLKAFIANLKSSSPTIRRTAAGSAVSICQHSRR
	*B. floridae*	HEAT_AAA	DAEIKVLLKTFLPNLRSASAVTRRTAASSLVTFCQHSRK
	*C. intestinalis*	HEAT_AAA	ESEIQGLLASFLKNLSHKSATMRRTACVCLHSVILNCRK
9	*H. sapiens*	HEAT_AAA	KLQERVLNNVVIHLLGDEDPRVRHVAAASLIRLVPKLFY
	*B. floridae*	HEAT_AAA	NCQQRLLEDIVLHLMGDDDYRVRHAATAALVRLVPRLFY
11	*H. sapiens*	HEAT_AAA	RLFEPLVIKALKQYTTTTCVQLQKQVLDLLAQLVQLRVN
	*B. floridae*	HEAT_AAA	RLFEPLVIKSLKLYTVTSSVTLQRQVLHLLAQLVQLRVN
15	*H. sapiens*	HEAT_AAA	DDTAKQLIPVISDYLLSNLKGIAHCVNIHSQQHVLVMCA
	*B. floridae*	HEAT_AAA	SEATKLLVPVLQDYLSKNIPPTAQCCIVHVEPHVLAMWA
add1	*H. sapiens*	HEAT_AAA	ARVVARILPQFLDDFFPPQDIMNKVIGEFLSNQQPYPQF
	*B. floridae*	HEAT_AAA	ARVVARILPTFLDDFFPAQDIMNKVIGEFLSSQQPHPQL
	*C. intestinalis*	HEAT_AAA	ARVMSKVLPSMLDDFFPAQDIMNKIIAEFISTLQPFPAS
add2	*H. sapiens*	HEAT_AAA	SPWVAAILPHVISRMGKLEQVDVNLFCLVATDFYRHQIEE
	*B. floridae*	HEAT_AAA	NPWVCALLPHVIGRMGLMETVDRKLFCITALDFYKNQITE
	*C. intestinalis*	HEAT_AAA	NRWISSMVPLIISRVHDPTLDVDWTCFCKAAVDFYTCQLSE

The consensus sequence of the most conserved HEAT repeats in H. sapiens, B. floridae and C. intestinalis huntingtin are shown.

ISSN: 1471-213X