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Figure 1 | BMC Developmental Biology

Figure 1

From: Dermal fibroblasts derived from fetal and postnatal humans exhibit distinct responses to insulin like growth factors

Figure 1

Proliferation response of dermal fibroblasts to IGF-I and IGF-II. A: The mean proliferation curve in response to IGF-I at 72 hrs for both FDF (open squares; n = 3) and MDF (closed diamonds; n = 3) in 0.4% FCS-containing medium. Error bars = SEM. (*p = < 0.05; **p = < 0.005). FDF only showed statistical difference at 100 and 300 ng/ml. MDF showed a statistical increase in proliferation at 25 ng/ml, 50 ng/ml, 100 ng/ml and 300 ng/ml compared to untreated controls. B: The mean proliferation curve in response to IGF-II at 72 h for both FDF (open squares; n = 3) and MDF (closed diamonds; n = 3) in 0.4% FCS-containing medium. Error bars = SEM. (*p = < 0.05). FDF showed a statistical increase throughout the concentration range compared to untreated controls. MDF showed a statistical significance from the untreated control at 100 and 300 ng/ml.

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