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Figure 7 | BMC Developmental Biology

Figure 7

From: Neuregulin3 alters cell fate in the epidermis and mammary gland

Figure 7

Increased proliferation in K14- Nrg3 epidermis. Immunohistochemical analysis shows an increase in Ki67 and CyclinD1 in the epidermis. (A and B) In non-transgenic epidermis (A), Ki67 is restricted to some basal cells. In K14-Nrg3 skin (B), Ki67 is expressed throughout the basal layer and in three to four suprabasal layers.(C) Quantification of immunohistochemical analysis with Ki67 antibodies. 500 cells were counted. Error bars indicate the standard deviation. The differences are significant between non-transgenic and K14-Nrg3 epidermis (p = 0.0176) using the paired student test. (D and E) In non-transgenic epidermis (D), CyclinD1 expression is restricted to some basal cells. In K14-Nrg3 skin (E), CyclinD1 is expressed throughout most of the IFE. The scale bar represents 50 μm.

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