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Figure 2 | BMC Developmental Biology

Figure 2

From: Neuregulin3 alters cell fate in the epidermis and mammary gland

Figure 2

K14- Nrg3 transgenic mice display hyperplastic epithelia and hair follicleab normalities. Histological analysis of dorsal skin from K14-Nrg3 and age-matched non-transgenic littermate. (A) Skin section stained with H&E from non-transgenic littermate at P7. (B) Skin section stained with H&E from K14-Nrg3 transgenic founder at P7. The transgenic epidermis shows hyperplasia and enlargement of cells and nuclei compared with non-transgenic littermates. Expanded suprabasal, granular and cornified layers are present in the interfollicular epidermis (IFE). A large infiltration of fibroblasts was observed in the transgenic skin. Hair follicles and sebaceous glands were also hyperplastic. (C) Four hair shaft types are present in a non-transgenic littermate.(D) Only one hair shaft type (zigzag) is present in a lower Nrg3 expressing K14-Nrg3 transgenic line that did form some sparse wavy hair. (E) Transgenic expression pattern of Nrg3 from K14-Nrg3 transgenic skin at P7. Nrg3 is expressed in the basal, suprabasal, and granular layers of the epithelium and in the outer root sheath (ORS) of hair follicles.(G, guard; Au, Auchene; Aw, Awl; Z, zigzag) The scale bar represents 50 μm.

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