Figure 4

Morphological variation at E17.5. Differences in morphology between Fgfr2^+/S252W mice and unaffected littermates at E17.5 (A, lateral view; B, superior view) and P0 (C, lateral view; D, superior view) and between Fgfr2^+/P253R mice and unaffected littermates at E17.5 (E, F) and P0 (G, H). For all views rostral is left, caudal is right. The linear distances pictured are limited to those that differed significantly by ≥ 5% between mice carrying one of the two Fgfr2 mutations and their respective unaffected littermates (using α = 0.10 confidence limits). The magnitude of these differences varies across the skull. Lines represent distances among landmarks that are significantly larger (blue) and significantly smaller (fuchsia) in mutant mice. Thin lines indicate linear distances that are increased/decreased by 5-10% in mice carrying one of the two Fgfr2 mutations while thick lines indicate linear distances that differ by >10% between unaffected and mutant mice. Bone segmented from HRμCT images is shown as partially transparent to better visualize the differences. See supplementary videos for a full 360-degree rotation view of differences in cranial morphology between Fgfr2^+/S252W mice and unaffected littermates at E17.5 [Additional file 3] and P0 [Additional file 5], and differences in cranial morphology between Fgfr2^+/P253R and unaffected littermates at E17.5 [Additional file 4] and P0 [Additional file 6].