Figure 3
From: Mechanisms underlying dual effects of serotonin during development of Helisoma trivolvis(Mollusca)
Pharmacological analysis of 5-HT receptors involved in retardation and acceleration of H. trivolvis development. (A-C). Development tempo expressed as changes in the length of embryos is modulated upon treatment with different 5-HTR agonists in a dose-dependent manner. Treatment with RS67333 (A) and 8-OH-DPAT (B) results in retardation, while treatment with 5-CT (C) – in acceleration effects. (D) Effect of combined application of agonists and antagonists on the embryos length after 84 h of incubation. Data were normalized to the control and shown as mean ± s.d. (***, p <0.001). (E) Effect of forskolin treatment on the embryos length after 84 h of incubation. Normalized values represent means ± s.d.; (***, p <0.001). (F) Effect of db-cAMP treatment on the embryos length after 84 h of incubation. Normalized values represent means ± s.d.; (***, p <0.001).