Table 3 KEGG Pathways enriched for genes upregulated in the inner cell mass or trophectoderm
From: Global gene expression of the inner cell mass and trophectoderm of the bovine blastocyst
Term | Genes |
|---|---|
Upregulated in Inner Cell Mass (A) | |
Antigen processing and presentation | CD74, CD8B, HSPA1L, HSPA6, PSME1, BoLA-DRB3 |
Complement and coagulation cascades | A2M, F2R, C1R, PLAUR, C4BPA, |
Chemokine signaling pathway | ITK, CCL24, CXCL7, GNAI1, GNB5, GNG7, PLCB1, STAT1, STAT4, STAT3 |
Axon guidance | EPHA4, CHP, DPYSL2, GNAI1, ROBO1, SEMA4G, SLIT2 |
Arrhythmogenic right ventricular cardiomyopathy (ARVC) | CDH2, DES, GJA1, ITGA2, TCF7L2 |
Pathways in cancer | CDKN2B, FGF12, FGF16, ITGA2 MMP9, PDGFRA, STAT1, STAT4, STAT3, TCF7L2, FOS, KIT,WNT |
Jak-STAT signaling pathway | IL12RB2, IL19, IL6ST, IL7, STA1, STAT4, STAT3, SPRY2 |
Hematopoietic cell lineage | CD1A, CD8B, ITGA2, IL7, KIT |
Upregulated in Trophectoderm (B) | |
Lysosome | ATP6V0A4, GM2A, NPC, CTSB, CTSH, CTSL2, CTNS, GLAA, GALC, MANBA, PLA2G15, SCARB2, ATP6V0C, SLC11A2 |
Steroid biosynthesis | NSDHL, CYP41A1, FDFT1, SC4MOL |
Aldosterone-regulated sodium reabsorption | ATP1B3, NEDD4L, PRKCG, SGK1, SFN |
Vascular smooth muscle contraction | ACTA2, ACTG2, CALD1, CALML5, ITPR2, MYLK, MYL6, PRKCH, PRKCG |
PPAR signaling pathway | ACSL4, AXSL6, FABP5, ACSL3, SCD, SCP2 |
Phosphatidylinositol signaling system | CALML3, ITPR2INPP4B, INPP5D, PRKCG, SYNJ1 |
Pantothenate and CoA biosynthesis | BCAT1, ENPP1, ENPP3 |
Terpenoid backbone biosynthesis | HMGCR, ACAT2, IDI1 |
Sphingolipid metabolism | UGCG, GLA, GALC, SGPP1 |
Steroid hormone biosynthesis | UGT1A1, UGT1A6, CYP11A1, CYP3A28, HSD3B1 |
Fatty acid metabolism | ACAT2, ACSL4, ACSL6, ACSL3 |
ABC transporters | ABCA3,ABCB1, ABCC2, ABCG5 |