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Figure 7 | BMC Developmental Biology

Figure 7

From: The long noncoding RNA RNCR2 directs mouse retinal cell specification

Figure 7

Domain-specific RNCR2-IRES-GFP fusion constructs selectively inhibit either amacrine or Müller glia differentiation. Dominant-negative RNCR2 constructs were electroporated in vivo at P0.5 and analyzed at P21. (A-B) Section immunohistochemistry reveals that RNCR2-5'-IRES-GFP overexpression led to an increase in amacrine cells (yellow arrowheads), (C-E) RNCR2-middle-IRES-GFP overexpression led to an increase in Müller glia (white arrowheads) and amacrine cells and RNCR2-3'-IRES-GFP overexpression led to an increase in Müller glia. (F) Each of the RNCR2-IRES-GFP domain-specific constructs showed an increase in INL cells compared to control **p < 0.003.

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