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Figure 8 | BMC Developmental Biology

Figure 8

From: Activation of p38 MAPK pathway in the skull abnormalities of Apert syndrome Fgfr2+P253R mice

Figure 8

Increased phosphorylated ERK1/2 and p38 and no change in phosphorylated PKCα and AKT in skull base tissues of Fgfr2+/P253Rat E17.5. A-D) Western blot analysis of different markers shows increased phosphorylated ERK1/2 and p38 and no change in phosphorylated AKT and PKCα. E, F) Scatter plots using normalized levels of of mutant phos/total/control phos/total shows increased ratio of phosphorylated ERK1/2 and p38 to total protein in the Fgfr2+/P253Ras compared to the wild-type skull bases. Each dot represents the analysis of data from one embryo. The bar represents the median value.

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