Teratogen-induced alterations in microRNA-34, microRNA-125b and microRNA-155 expression: correlation with embryonic p53 genotype and limb phenotype

Table 3 Effects of p53 on CP-induced limb phenotype (dose of 20 mg/kg)

Tested embryonic structure	p53 genotype	Number of tested embryos	Number of embryos exhibiting:
			Digit anomalies	Limb reduction anomalies
Forelimbs	+/+ and +/-	64	24(37.5%)	0
	-/-	28	0*	0
Hindlimbs	+/+ and +/-	64	62 (96.9%)	24 (37.5%)
	-/-	28	4 (14.3%)*	0*

Differences between p53 positive and p53 negative embryos are statistically significant (the Fisher exact test, p < 0.05).

ISSN: 1471-213X