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Figure 2 | BMC Developmental Biology

Figure 2

From: SEL1L deficiency impairs growth and differentiation of pancreatic epithelial cells

Figure 2

Impaired pancreatic epithelial growth and branching morphogenesis in Sel1lβgeo/βgeoembryos. (A-D) Immunohistological analysis of the developing pancreas of wild-type and Sel1lβgeo/βgeoembryos at E11.5 and E13.5; the genotypes of the pancreatic sections are indicated as +/+ and -/-, respectively. The following antibodies were used: Pdx1 (A-D, green) and insulin (C-D, red). (A-B) The dorsal and ventral pancreatic buds in Sel1lβgeo/βgeoembryos are fused together. (C-D) The dorsal pancreatic bud of Sel1lβgeo/βgeoembryos exhibits a markedly reduced epithelial size and an impaired branching morphology. (E-F) Statistical analyses of estimated pancreatic epithelial sizes of wild-type and Sel1lβgeo/βgeoembryos at E11.5 (E) and E13.5 (F). Data were from three sets of wild-type and Sel1lβgeo/βgeoembryos. No significant difference in the epithelial sizes of wild-type and Sel1l-deficient pancreas at E11.5 was detected (E). At E13.5, the pancreatic epithelium of Sel1l-deficient embryos was significantly smaller (F). Scale bar: 100 μm.

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