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Figure 7 | BMC Developmental Biology

Figure 7

From: Activated Ras alters lens and corneal development through induction of distinct downstream targets

Figure 7

Ras targets in the lens and cornea. In situ hybridizations were performed on ocular sections of nontransgenic (NT) (A, C, E, G, I) and Pax6-Ras transgenic (B, D, F, H, J) E13.5 embryos using 35S-labelled Erm, Pea3, Spry1, 2 and 4 riboprobes. Dark-field images were overlaid on respective bright-field images and silver grains were colored red. Erm (B) expression was upregulated in the Ras transgenic lens and cornea. Pea3 (D), Spry1 (F) and Spry2 (H) expression was upregulated in the Ras transgenic corneas. Abbreviations; C, corneal epithelium; Cj, conjunctival epithelium; le, lens epithelium; lf, lens fibers; nr, neural retina. The scale bar (I) represents 100 μm in panels A-J.

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