Figure 5
From: The functional genomic response of developing embryonic submandibular glands to NF-kappaB inhibition
SN50 treatment induces a significant increase in activated (phosphorylated) p53. We detect a notable increase in activated p53 (brown color) in E15 + 2 SN50-treated (100 μg/ml) explants (B) compared to control (A). Bar: 50 μm. C. Quantitation of activated p53 in control (CONT) and SN50-treated E15 + 2 explants. The data presented here represents 3 independent samples. Mean ± SEM percent positive epithelium: each bar is the mean of 3 independent samples, each sample representing counts in 3 randomly selected regions of that sample; percents were arcsin transformed for analysis. A highly significant greater than 4-fold increase in activated p53 is seen between control and SN50-treated explants.